Developing assay formats Screening for antagonists Characterization of hits
نویسنده
چکیده
The ability to antagonise c-MET oncogene activity with agents affecting the interaction Met tail/SH2-containing transducer Grb2, is expected to result in inhibition of both metastatic invasion and proliferation. The goal of this study was to establish a discovery strategy to identify small organic molecules as antagonists of Met oncogene activity in primary and metastatic tumors by inhibition of the interaction between Met tail and the SH2-containing transducer Grb2. Stay on track in drug discovery Driving towards new anti-cancer drugs
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